Shoring your immunity: a multipronged approach

For the first 30 years of my life, I thought my immune system was pretty awesome. I would fall sick 1-2 times a year, and the infection with fever and malaise would last maybe 3-4 days. Not too shabby, right?

Then, I discovered I was Vitamin D-deficient, and had probably been so all my life – my levels were around 16 ng/mL. On continuous supplementation to correct for this,  my blood levels have held steady at 40-50 ng/mL. Many things changed subtly. My skin improved,  I gained some badly needed weight, and interestingly,  over the next 4 years, I never got really sick. Nasty infections would come around, but at the worst, I would be under the weather for a day – there was never a three-day bout.

Then, I had a baby. Via surrogacy, yes, but the first days were still mentally stressful. I did not appreciate how much so till I had my first 15-day cold, the first in recent memory. With a baby at home and the sleep deprivation of the first year, I quickly realized I needed MORE.

Now, I was already doing much more for my daughter, which I have covered here. I made sure that:

  1. She was vitamin D-replete: Vitamin D’s role in infection defense is, in part, through its requirement for making the anti-microbial peptides cathelicidin and beta-defensin-1, which form an important part of the first line of defense against infections. Overall, vitamin D is vital for optimal immune function, and children who fall ill repeatedly routinely turn out to be vitamin D deficient.
  2. She got a rather unique probiotic, Lactobacillus reuteri, which is interesting because it is the only Lactobacillus species (out of 10 examined) found consistently in a variety of birds and mammals, suggesting that it may play an important role in health. Indeed, it has been shown to protect against infections, and interestingly, protected against cancer in a single mouse study; now, one cannot conclude that this probiotic will have the same effect in humans, and this topic also remains a difficult one to study. Overall, there have been many studies examining this bacterial strain in multiple contexts (protection against infections, dental carries, etc.), and the preliminary results overall indicate that this is a very good choice if one were attempting to use probiotics to improve immune functioning.
  3. She got plenty of lauric acid via virgin coconut oil in her formula: this fatty acid, which is most abundant of its type in breast milk, also has potent anti-microbial effects. I talk about them at length in this post.

Now, thanks to Linus Pauling, when people fall sick, they dive for the Vitamin C, and think they have done enough. While it appears to have some usefulness (anti-oxidant, anti-inflammatory and even anti-microbial properties), its effectiveness in as reducing infection severity and length may be limited by itself.

Enhancing Immunity

Basically, a MULTIPRONGED approach may work best to protect yourself against falling ill.  I developed this arsenal after much thought:

  1. Vitamin D: Maintain repleteness (ideally, blood levels between 30-45 ng/mL) via continuous supplementation or sunblock-free sun exposure.
  2. Probiotics: I recommend the BioGaia probiotic (Lactobacillus reuteri) for maintenance (this has potential anti-microbial effects and protects against both respiratory infections and GI infections). When suffering from a GI infection, alternating BioGaia with a very different probiotic, Florastor (Saccharomyces boulardii, available as Econorm in India) will be more effective. Two points to emphasize:  1) Random, unstudied probiotic supplements that currently flood the market are likely to be utterly ineffective and a waste of money. 2) Florastor is extraordinarily effective for stopping GI infections. 
  3. Vitamin C: While getting this from food is best, if one wishes to take a supplement, a  bio-available  form (for example, Madre C, which contains acerola cherry and indian gooseberry extract) is recommended.
  4. Extra virgin coconut oil, which has anti-microbial and anti-viral effects.
  5. Omega 3 fatty acids: While these are mainly associated with roles in brain building and protecting from stroke/heart attacks, new evidence shows that they also have a role in immune functioning; specifically, they appear to enhance B cell immunity.
  6. Turmeric with black pepper:  Turmeric, which has used medicinally for centuries, has an eye-popping array of useful properties,  including anti-inflammatory, anti-viral, anti-microbial, and anti-cancer effects.  But despite all of these useful properties, even taken in vast quantities orally, it shows almost no effect because of the low solubility and very poor bio-availability of its component curcuminoids. There has been a lot of research aimed at addressing these issues. But sitting at home, what can you do? While this is by no means optimized, piperine, a component of black pepper, increases the blood levels of curcumin considerably by inhibiting its removal through the liver.  Here is my turmeric home brew: milk + fresh ground black peppercorns + turmeric + coconut oil (for lauric acid). It may be a good idea to mix the turmeric in coconut oil before adding to the milk, given that curcuminoids are fat-soluble. Alternately, check out supplements here
  7. Elderberry Extracts: These, like turmeric, have been medicinally used for centuries. Their undoubted anti-viral effects have been proven in the case of influenza in mice, in birds,  in vitro, and even in one very small clinical trial.

Of these, the first five (Vitamin D, probiotics, vitamin C, virgin coconut oil, and Omega 3 fatty acids) should ideally be taken regularly to maintain health: most of these have functions that go beyond optimization of immune responses.

In contrast, elderberry extracts should not ideally be taken daily. A great many people have expressed interest in doing exactly this, and I would have to advice against this stratagem: elderberry is certainly not required for normal functioning, unlike Vitamin D, vitamin C, omega 3 fatty acids, and even probiotics (which may play a role in shaping the gut microbiome, which in turn has a tremendous effect on health).  Elderberry extracts actually exert their anti-viral effects in part by inhibiting ribsome functioning,which means they affect protein production, and hence in theory could affect any rapidly dividing cell in a dose-dependent manner.

Small (non-medicinal quantities) of turmeric in combination with black pepper can be taken daily by older people: this may be a particularly good idea for individuals with or at risk for metabolic syndrome. There is a wealth of literature on this, but I will highlight this analysis which suggests that it may be helpful in diabetics. If anybody wishes to take medicinal quantities of turmeric in a bio-available form for any number of conditions (cancer, osteoarthritis, other chronic pain conditions, metabolic syndrome, and so on) I would suggest that they do so in consultation with their doctor.

I do not advice that children be given turmeric + pepper daily, though it is definitely advisable to give turmeric + black pepper, as well as elderberry extracts if they are showing signs of infection.

The past few months, I have had 3 threatened infections, all of which were (coincidence or not) staved off by taking all of these in combination. I have also tried these (absolutely safe) experiments on all my family members, and they claim all of these (especially the probiotic and the turmeric-in-milk-with-pepper home brew) have helped. All of this is done for my toddler daughter as well, and again, it really seems to help, especially the Florastor + BioGaia combination for GI infections.

More than reducing the incidence and severity of minor infections, these easy, safe, and relatively inexpensive strategies, if in play from an early pointmay have a far more important role: to reduce the severity of illness following infection with the very nasty bugs (dengue viruses, EHECs, MRSA, malarial parasites, and so on) thus reducing the risk for hospitalization, a requirement for intensive care, or worse.  The gravity of this point cannot be emphasized enough.

Many people have asked about sources of these, so here is a Where to Buy list:

ADULT SUPPLEMENTS:

INFANT/TODDLER SUPPLEMENTS

OTHERS

Advertisements
This entry was posted in Living healthy. Bookmark the permalink.

14 Responses to Shoring your immunity: a multipronged approach

  1. Augusta19 says:

    I am a big fan of your immunology posts and have taken detailed notes from today’s post. THANK YOU! Gummy has been very ill lately (pneumonia and doubly ear infection), which is solidifying my resolve to focus on her immunity (I’ve been giving her BioGaia nonstop, but it’s time to make a more concerted effort in terms of the coconut oil and vitamin D).
    And for myself, I will be using your recommendations to avoid getting sick. I especially like the recommendation about turmeric and peppercorn milk (i’m going to need to use soy milk because of my lactose intolerance, but I suspect that is ok). I like cooking with turmeric, but that’s maybe only 1-2 dishes per month; not enough! Thank you so much for this post, J.

    Like

    • Ouch…poor Gummy! Yeah, a vitamin D test would be a good idea to see where you stand. Also, ALL of these things (even the elderberry and turmeric-in-milk with a smidge of pepper—her spice tolerance level is that of an Indian adult now, thanks to BLW) I subject poor G to as well if she is under the weather, and the combinations really seem to help.

      About elderberry preps for kids: I use this one (nasty raspberry flavor and mind blowing amounts of fructose), but what can you do?: http://www.naturesway.com/Sambucus-for-Kids-4-fluid-oz

      Like

  2. sarahdreams big@hotmail.com says:

    I love this post – thanks for sharing!

    Like

  3. Anisha says:

    My daughter has hyper active airways. Can any of this help her.

    Like

    • Well, the BioGaia probiotic (available in the US, but not India) in a short term studies was shown to have effects on calming hyperactive airways, but it seems to be useful only as long as you give it continuously.

      Also please make sure she is vitamin D-replete, not deficient, by checking blood levels (the majority of Indians—adults and children alike–are deficiency if they do not supplement). Correcting the deficiency is really helpful in the long run: Vitamin D does a lot more in the immune system other than just fight infections.

      Like

  4. Chaitra says:

    This blog was all I was looking for. After 5month pp i was hyper sensitive to allergies(I had these before pregnancy too and I use to take calritin everyday and it was not bad at all). Even minimal exposure to env like going for a walk/playing in park etc made my lips itch and followed by swelling. This itch n swelling then slowly used to spread on the cheeks and face followed by itch Scalp followed by tummy upset. I consulted physicians they gave me some benedryl shorts and Benedryl 125mg allergy pills. Whenver i get these symptoms.. I used to take these tablets. But sometime situation used to get worse.I consulted other physician and he put me on some steroids for a week and asked to take molekulast SOD every day for a month.This tablets made me lazy like hell.. drowsy…boring with full of negative thoughts.. and more imp to put on weight like 5 kgs in a month or so….I felt good and fresh only when I was on steroids. But my allergy reactions didnt stop there.. even with these medications i had allergy attacks. I consulted Allergy specialist.. He again repeated the same and did all sort of testing and told me nothing which I already didnt knew. I have allergies for shell fish(Crab/Lobster/Shrimp/Cockrach) almost all sort of trees in georgia and dust mites. I dont eat any meat other than Chicken.. He did mention tht he is not sure why My lips n face is getting swollen but itch n other stuff he said expected due to allergy reactions. As Allegra made me very weak n Zyrtec made me sleepy(I work n cant afford this) he put me on Clarenyx(pardon my spelling or) and asked me to take allergy shorts. When i enquire about the dosage of shots.. I was shocked… its like 27 shorts for 27 weeks until u build ur immunity and after tht one shot every 2 weeks. I said BIG NO. I want to build immunity naturally and shed wt. which I gained due to these Steroids. So taking Neem and Ashwagandha tablets (2 each) followed by Vitamin D 5000mg(Suggested by Physician) and pre-natals. I already feel fresh n happy with new medication list… OK now the Question is Can I take probiotics and Vitamin C along with what i’m taking now. Will it help??

    Thank you so much for the patienceApologies for the long post …..

    -Chaitra

    Like

    • Yes, probiotics (the right ones– A probiotic named VSL#3 seems to have some protective effect, and also maybe Biogaia) will probably help, and and vitamin C is a good idea: getting it through food is a great idea, or go with a food-derived form.

      As a note, KEEP taking vitamin D (maybe reduce you dosage to 2000 IU/day) after a while, because if you stop, in a few months or longer,you will be deficient again. Check your levels through a blood test, and make sure you stay within the 30-45 ng/mL zone.

      But these are not quick fixes. Allergies are the hardest thing to fix, because the balance of the immune system has been overturned. Do all this, but please discuss any change in prescribed medication with your doctor.

      Best of luck!

      Like

  5. Shilpa says:

    Hey Jaya, great article as always! Couple of questions:
    1. Is there a brand of vitamin D that you recommend?
    2. Would you give probiotics to kids everyday?

    Like

    • Hey Shilpa! Glad you found this useful. To answer your questions:
      1) Any vitamin D which is in oil is good (Carlson D drops is what I currently use).
      2) I thought I would give BioGaia everyday for the first few years, and stop. But the problem with this really amazing probiotic is, once you stop giving it, it seems to disappear from the gut after a while. Given its many useful properties (possibly protects against cancer, allergies, and asthma —only if given continuously—and acute infections, and changes the microbial composition of the gut), I think I will keep giving it, maybe once every 2-3 days instead of everyday. Plus I definitely keep it at home for if anybody (adults included) are sick: it really seems to help then, possibly through the broad-spectrum antimicrobial (reuterin) it makes. The other probiotic I mention, Florastor, is highly effective for any food poisoning/GI upset. G has had 2 episodes to date, and within 1-2 sachet doses of this, the diarrhea would stop and the vomiting would cease. As a result, she has never even gotten dehydrated or had a fever or even had any appreciable weight loss during a stomach upset, and it resolves within 24-48 hours.

      Like

  6. Shilpa says:

    Thank you, Jaya. I agree about Florastor! We’ve given it to K in the past during illness, but may need to give it more regularly.
    I’m assuming you give vitamin D drops to G. How about yourself? Tablet form issume?

    Like

  7. Arti says:

    Hi Jaya,
    This is a really interesting article. Thank you for writing this information to help people such as myself understand immune boosters better. I have a couple of questions.
    1. I have a 15 month old baby. I used to give him gerber soothe colic drops (Biogaia) everyday. What should I be giving him on a daily basis at this age?
    2. Ever since I had my son my immune system and sleep patterns have completely been thrown off. What do you recommend I take to boost my immune system on a daily basis?

    Like

  8. Toral Vyas says:

    Thanks for Sharing the information. My son has severe eczema. We use topical steroid cream occasionally when it is really bad,. We apply turmeric.neem oil and coocnut oil on the skin to help the itching..He is 7 months and has been having eczema since he was 2 months. Do you think Probotics would help ?

    Like

  9. Amrita says:

    Hi

    Thank you for sharing this. Needed to know if there are any indian locally available substitutes to these
    And also, my son is fb and formula fed so do you recommend mixing the extra virgin coconut oil in the formula?

    Like

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s